GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1056667 | 1 | rs6922824 | chr6:26553815 | BTN2A3 | chr6:26422317-26431927:+ | -0.18 | -4.36 | 1.6E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6922824 | chr6:26553815 | BTN3A3 | chr6:26440763-26453642:+ | -0.12 | -3.35 | 0.000885 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6922824 | chr6:26553815 | HCG11 | chr6:26521934-26527610:+ | 0.22 | 4.42 | 1.22E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6922824 | chr6:26553815 | HMGN4 | chr6:26538572-26547162:+ | 0.15 | 3.88 | 0.000119 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6922824 | chr6:26553815 | LOC100270746 | chr6:26987146-26988085:- | 0.16 | 3.76 | 0.000191 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6922824 | chr6:26553815 | ZNF322A | chr6:26634612-26659963:- | 0.16 | 4.53 | 7.58E-6 | Educational attainment |
| THCA | cis | rs9473555 | 1 | rs6923124 | chr6:49419864 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.64 | 2.89E-8 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs6923124 | chr6:49419864 | MUT | chr6:49398994-49431031:- | 0.28 | 9.64 | 3.23E-20 | Folate pathway vitamin levels |
| THCA | cis | rs1577917 | 1 | rs6923148 | chr6:86767786 | SNHG5 | chr6:86386726-86388451:- | 0.55 | 12.77 | 2.43E-32 | Response to antipsychotic treatment |
| THCA | cis | rs7762018 | 1 | rs6923339 | chr6:170128033 | C6orf70 | chr6:170151721-170181617:+ | 0.25 | 5.11 | 4.56E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs7762018 | 1 | rs6923339 | chr6:170128033 | WDR27 | chr6:169857307-170102159:- | -0.18 | -5.54 | 5.0E-8 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs2031365 | 1 | rs6924373 | chr6:87804222 | C6orf164 | chr6:88032306-88109459:+ | 0.23 | 4.6 | 5.4E-6 | Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) |
| THCA | cis | rs1056667 | 1 | rs6924838 | chr6:26571756 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.22 | 2.98E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6924838 | chr6:26571756 | HCG11 | chr6:26521934-26527610:+ | -0.21 | -4.11 | 4.7E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6924838 | chr6:26571756 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.16 | 3.71E-5 | Educational attainment |